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doi: 10.1016/j.ejps.2025.107073 Summary Keywords hepatoprotection, hepatotoxicity, morin, nano-formulations, oxidative stress, synergistic therapy Citation Sivalingam AM (2026) Crosstalk along the gut-liver axis modulates glutathione and cadmium-induced hepatotoxicity

Regarding PPs applications in alleviating AFs-induced health challenges, there are several key points should be highlighted before consideration of these metabolites for large-scale studies

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Clinical data with epacadostat (investigational drug for cancer inhibiting IDO1 an immune modulating enzyme indoleamine -2,3-dioxygenase-1) showed that hydroxyamidine based inhibitors are extensively glucuronidated in humans